Sentence examples for maximum tolerated activity from inspiring English sources

Maximum tolerated activity was defined if two or more patients out of six reached ALT.

Haematological toxicity was the dose-limiting toxicity and the maximum tolerated activity was relatively low (1.8 GBq/m2).

Pre-therapy dose planning, as done in clinical studies, could maybe replace the maximum tolerated dose or the maximum tolerated activity studies in pre-clinical therapy studies.

In another study, we found a maximum tolerated activity of 21.2 ± 1.7 MBq in the presence of i.p. l-lysine as kidney protectant prior to the 213Bi-DOTATATE treatment; in the absence of l-lysine, the maximum tolerated activity was <13.1 ± 1.2 MBq (manuscript in preparation).

Mice were injected with a) 6 MBq (50% maximum tolerated activity (MTA), 25 μg, 100 μl) 177Lu-DOTA-chCE7 177Lu-DOTA-chCE7 177Lu-DOTA-chCE7(25 μg, 100 μl) or c) PbS into the tail vein.

Activity limiting toxicity occurred in two of six who received activities of 5000 MBq and maximum tolerated activity was defined at this activity level.

Barendswaard et al. showed that the maximum tolerated activities of 131I were 18.5 MBq (0.5 mCi) in this model system.

Interestingly, in the Raji Burkitt's lymphoma model, the class I/II DAC inhibitor vorinostat administered at its maximum tolerated dose (MTD) lacked activity, whereas AR-42 showed statistically significant activity without discernable toxicity.

Thus, the aim of this phase I/II study was to evaluate the maximum tolerated dose (MTD), the activity (response, time to treatment failure, survival) and toxicity profile of this combination in patients with stage IV breast cancer patients previously treated with chemotherapy regimens including taxanes or anthracyclines.

This phase 1 dose-escalation study evaluated the maximum tolerated dose (MTD), safety, preliminary activity, pharmacokinetics, and pharmacodynamics of HCQ in combination with TEM in cancer patients.

The aims of this phase I study were to establish the maximum tolerated dose, safety profile and activity of liposomal daunorubicin, DaunoXome (NeXstar Pharmaceuticals), in the treatment of metastatic breast cancer.