Sentence examples for maximum tolerable toxicity from inspiring English sources

At any point in a trial, the dose given is that with estimated toxicity deemed closest to the maximum tolerable toxicity.

It is important to note that most chemotherapeutics display high levels of toxicity, and that their maximum tolerated dose is often dictated by the maximum tolerable off-target toxicity.

We first determined toxicity profiles, maximum tolerable doses (MTDs) and plasma levels of the two HDAC8-selective inhibitors Cpd2 and PCI-48012 for application in mice in vivo.

The objectives of this study were (i) to assess the safety and toxicity profiles of this combination; (ii) to determine the dose-limiting toxicities (DLTs), the maximum tolerable doses (MTDs), and the recommended doses for further trials; and (iii) to examine the effect of irinotecan on R115777 pharmacokinetics and vice versa.

Phase I trials of flavopiridol in children have revealed that its toxicity profile, pharmacokinetics, and maximum tolerable dose were similar to that in adults, indicating that using flavopiridol in RT patients, a largely pediatric population, is feasible [ 15].

The toxicity profile, feasibility, and maximum tolerable dosage of the combination of gemcitabine/5-FU/Folinic Acid/Cisplatin was investigated in a past phase-I trial of our study group [ 18].

Doses were based on previous experience and reflected maximum tolerated mouse doses that were associated with tumour response with tolerable toxicity (Ganapathi et al, 1988).

The dose-limiting toxicity was neutropenia at the maximum tolerable losoxantrone dose of 45 mg m−2.

Dose-limiting toxicity was organ toxicity owing to graft-versus-host disease, and the maximum tolerable dose was 5 mg.

AE: adverse event; AUC: area under the concentration time curve; Cmax: peak plasma concentration; CR: complete response; DLT: dose-limiting toxicity; HER2: human epidermal growth factor receptor 2; MTD: maximum tolerable dose; PI3K: phosphatidylinositol-3 kinase; PR: partial response; QOD: every other day; QW: once weekly; SD: stable disease.

The observed kidney toxicity for therapy with 177Lu-DOTATATE is lower, with a maximum tolerable absorbed dose yet to be defined [3, 27].