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These concentrations approximate the maximum tolerable plasma levels in humans.
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We first determined toxicity profiles, maximum tolerable doses (MTDs) and plasma levels of the two HDAC8-selective inhibitors Cpd2 and PCI-48012 for application in mice in vivo.
CRM: certified reference material; ICP-MS: inductively coupled plasma - mass spectrometry; PMTDI: permitted maximum tolerable daily intake.
In phase 2, subjects will be randomized in a 2 1 randomization scheme to receive the maximum tolerable dose of MSCs determined in phase 1 or Plasma-lyte A placebo.
AE: adverse event; AUC: area under the concentration time curve; Cmax: peak plasma concentration; CR: complete response; DLT: dose-limiting toxicity; HER2: human epidermal growth factor receptor 2; MTD: maximum tolerable dose; PI3K: phosphatidylinositol-3 kinase; PR: partial response; QOD: every other day; QW: once weekly; SD: stable disease.
Only if patients reach the maximum tolerable dose of statins, or face unbearable side effects, should they try Vytorin.
The maximum tolerable concentration of arsenic in dusts during an eight-hour day is 0.5 milligrams per cubic metre.
But while doctors now generally use the maximum tolerable dose of each drug, Celator says the ratio of the drugs is what matters more.
difference in foot length is outside Bertillon's maximum tolerable deviation for saying two sets of measurements derived from the same body.
The maximum tolerable concentration of antimony dust in air is about the same as for arsenic, 0.5 milligrams per cubic metre.
maximum tolerable concentration.
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