Sentence examples for maximum tolerable doses from inspiring English sources

The maximum tolerable doses that evolved from these studies are currently used in the CRITICS study.

We first determined toxicity profiles, maximum tolerable doses (MTDs) and plasma levels of the two HDAC8-selective inhibitors Cpd2 and PCI-48012 for application in mice in vivo.

In the treatment of PHN and other neuropathic pain conditions, single-drug therapy may not provide sufficient analgesia even when administered at maximum tolerable doses [ 46].

If within three months, using SC at the maximum tolerable doses, patients did not meet the response criteria, MTX therapy was associated with other synthetic DMARDs.

The ureters, blood vessels, soft tissue, bone, and pelvic nerves are structures at risk of injury from IORT. 13, 44, 47, 48 IOERT doses of 10 20 Gy are the maximum tolerable doses when combined with EBRT.

Estimated maximum tolerable doses and fractionally lower doses of each compound were administered to groups of 50 male and 50 female rats and mice for 2 years, followed by sacrifice, necropsy, and histopathological examination of major organs and tissues.

Overall, MK-2206 was well tolerated at biologically active doses, with the maximum tolerable dose (MTD) established at 60 mg QOD; the MTD for the QW dosing schedule (expected to be less than 250 mg) was not established due to early discontinuation of the trial.

A recent trial showed that the combination of nortriptyline and gabapentin at the maximum tolerated dose was more effective than either monotherapy, despite a lower maximum tolerable dose as compared with monotherapy.

But while doctors now generally use the maximum tolerable dose of each drug, Celator says the ratio of the drugs is what matters more.

Only if patients reach the maximum tolerable dose of statins, or face unbearable side effects, should they try Vytorin.

Dose-limiting toxicity was organ toxicity owing to graft-versus-host disease, and the maximum tolerable dose was 5 mg.