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No deviation from the maximum target dose (195UI) was allowed.
The 75 mg BID cohort was discontinued early; therefore, 125 mg QD was the maximum target dose.
In the study reported here, combination therapy with motesanib 125 mg QD plus gemcitabine (1000 mg m−2) was well tolerated and 125 mg QD was established as the maximum target dose.
NPC bell shape like lesion treatment planning method is based on dose bricks concept which can provide maximum target dose and minimize dose of critical organs, especially in parotid glands.
The aim of this study was to determine the maximum target dose and the pharmacokinetic profile of motesanib when administered in combination with gemcitabine in patients with advanced solid tumours, and to assess the safety and efficacy of this treatment regimen.
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The maximum target doses for subjects weighing <40 kg were: lisinopril 10 mg, losartan 25 mg, and atorvastatin 10 mg.
As for standard therapy, four trials aimed at reaching maximum recommended target dose of individual ACE inhibitor therapy [24], [26], [28], [31].
24, 25 When added to metformin, the reduction in HbA1c with dapagliflozin titrated to maximum tolerated dose (target dose 10 mg daily) was found to be non-inferior to glipizide at the maximum tolerated dose (target dose 20 mg daily) (both −0.52%; confidence interval [CI]: −0.60, −0.44) after 52 weeks of therapy.
Maximum importance was given to target dose coverage.
Atomoxetine was titrated to a target dose of 1.2 mg/kg/day (maximum dose 1.4 mg/kg/day).
Dose for OROS methylphenidate was titrated to a target dose of 1.08 mg/kg/day (maximum dose 1.2 mg/kg/day).
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maximum target identity
maximum target displacement
maximum target temperature
maximum target coverage
maximum target market
maximum target synchronization
maximum target illuminance
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maximum target cell
maximum target site
maximum target depth
maximum target array
maximum target value
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maximum target limit
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