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However, in Groups C and D combined, the maximum severity was higher in the vaccines than the placebo group (p = 0.036 and p = 0.028 after any DNA injections and the rAd5 boost, respectively).
Excluding those patients with hypogammaglobulinaemia at time of first rituximab, the median time to develop hypogammaglobulinaemia was 18 months (1 65), and median time to the hypogammaglobulinaemia category of maximum severity was 35 months (1 70).
Time-to-event analyses in phase III trials of regorafenib confirmed clinical experience that, as with sorafenib and sunitinib [ 66], HFSR tends to occur shortly after the start of treatment (median time to first occurrence was 15 days in the phase III study in colorectal cancer [ 67]), and the severity is also likely to peak early (medium time to maximum severity was 22 days in that study [ 67]).
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Because maximum pain severity was already captured in section Pain severity and location (Fig. 2), the "most frequent" pain was considered more relevant in this context.
First, to examine whether the results were due to differences in AKI severity, we restricted our analysis to those whose maximum AKI severity was Stage 1.
The disease developed rapidly and the maximum of severity was observed between 9 and 12 days.
In the case of multiple SIs, duration from the oldest was specified as the SI duration at study baseline, and similarly the maximum SI severity was treated as the SI severity.
The mean maximum score, representing disease severity, was calculated as the mean of the maximum score of all sick mice in the respective groups.
Maximum treatment-emergent AE severity was mild-to-moderate in the majority of patients in both treatment groups among both age groups.
With regards to oral systemic therapies, one random effects meta-analysis including 219 participants from two unblinded RCTs [ 32, 33] suggested that the maximum extent of RISR severity was significantly lower in those who received oral Wobe-Mugos E (MD -0.92, 95% CI -1.36 to -0.48, p < 0.0001) (see Figure 7).
The maximum total score is 46 points, and the maximum severity score is 39 points [ 34].
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