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Daily serum creatinine measurements were available for days 1 14 after study enrollment along with the maximum serum creatinine value from days 14 to 28 and all measurements from the 48 h prior to enrollment.
Urinary [TIMP 2]*[IGFBP7] maximum values within 24 h after surgery were associated with a comparable sensitivity (0.83) and specificity (0.78) (AUC 0.838, 95 % CI 0.632 1.0, SE 0.105, p = 0.007, cut-off 0.89) with maximum serum creatinine and lowest eGFR being associated with a lower sensitivity and specificity.
We used maximum serum creatinine level to category RIFLE class.
Maximum serum creatinine was preceded by platelet count nadirs by a median of 4 days.
aIndicates cases for which eGFR calculated for the minimum and maximum serum creatinine values classify patients in different CKD stages.
C: ARF, with a maximum serum creatinine level ≥ 200 μmol/l at day 1 of ICU admission.
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Postoperative renal dysfunction was defined as ≥ 30% increase in the preoperative-to-maximum postoperative serum creatinine level within 7 days after surgery [ 19].
The mean minimum to maximum range in serum creatinine values was 38.7 μmol/L.
Patients were followed until time of hospital discharge or death and were staged according to the maximum increase in serum creatinine using the RIFLE classification.
In addition, the median maximum value of serum creatinine during the course of colistin treatment was 0,80 mg/dl among this group of patients.
The incidence of CIN, defined as a maximum increase in serum creatinine concentration of more than 44 μmol/L or 25% within 48 hours after exposure to CM, was 6.5% (16/246) in the whole study cohort.
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