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A final sensitivity analysis was performed on patients with a maximum seroconversion interval of 6 months, using the first HIV-1 RNA measurement after seroconversion as dependent variable.
Other studies restricted patient selection to seroconverters with a maximum seroconversion interval of 6 months [9] or 12 months [7], [10].
In a final sensitivity analysis, including 751 patients with a maximum seroconversion interval of 6 months, the mean of the first HIV-1 RNA concentration taken after seroconversion was 0.48 log10 copies/ml (95% CI 0.26 0.71; p<0.0001) lower for seroconverters before 1996 and 0.17 (0.00–0.35; p = 0.05) lower between 1996 2002 compared to 2003 2007.
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We assumed that seroconversion interval and proportion seroconverting did not differ by age group [5].
In this example, we utilize information on the temporal distribution of cases as estimated from clinical surveillance data combined with information on seroconversion interval and the exact timing of each serum sample to estimate incidence by week.
Therefore we used multiple imputation to assign dates of seroconversion, randomly allocating a date within the seroconversion interval with a constant hazard throughout the interval.
To more closely examine the temporal relation between maternal infection and breastfeeding associated transmission, we repeated the analysis restricting postnatal seroconverter mothers to those with seroconversion intervals of less than or equal to 90 days (hereafter termed "short seroconversion interval").
In these corrected formulas, we used an estimated mean seroconversion interval of 155 days in accordance with package insert guidelines.
The median duration of the HCV seroconversion interval between visits was 4.0 months, interquartile range (IQR) 3.7, 5.1 months.
On finding HCV seroconversion (defined as the presence of HCV antibodies in a previously seronegative individual), we tested samples taken between these two visits to indicate the seroconversion interval.
Maximum seroconversion occurs in the first year with not much additional benefit on continuing treatment into the 2nd and 3rd years.
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