Sentence examples for maximum secretory capacity from inspiring English sources

The hypothesis that the intravenous glucose causes a stimulation that corresponds to the maximum secretory capacity of the β-cells has actually been tested in several experiments where β-cell function was stimulated by hyperglycemic clamps.

Collectively, these findings argue that the subset of α cells in α-V59M islets that remain electrically active operate close to their maximum secretory capacity already at 1 mM glucose, accounting for the smallness of the adrenaline effect.

Thus, a situation might occur where the intravenous glucose elicits a response corresponding to the maximum secretory capacity of the β-cells, and in this situation, oral administration of glucose would not be able to elicit a greater insulin response.

Furthermore, as discussed above, in patients with type 2 diabetes, infusions of even very large supra-physiological doses of GIP were unable to enhance insulin secretion further, a finding that could be compatible with the assumption that the maximum secretory capacity was reached (38).

Arginine was administered at t = 260 min during the hyperglycemic clamp to estimate maximum insulin secretory capacity at a steady-state glucose concentration of 15 mmol/L (11).

Arginine was administered during a hyperglycemic clamp to measure maximum insulin secretory capacity at a steady-state glucose concentration of 15 mmol/l (17).

Steady-state blood glucose concentrations at 15.0 mmol/L were sustained with a variable 20% glucose infusion for 80 min. Thereafter, 5.0 g arginine was administered to measure maximum insulin secretory capacity at a steady-state blood glucose concentration of 15.0 mmol/L.

This test was primarily aimed at evaluating the maximum β-cell insulin secretory capacity, but glucagon levels were also measured.

Acute insulin responses to arginine (AIRarg) were measured at baseline and after 6 months of treatment with 5 days of drug washout under fasting, 230 mg/dL (glucose potentiation of arginine-induced insulin release [AIRpot]), and 340 mg/dL (maximum arginine-induced insulin release [AIRmax]) hyperglycemic clamp conditions, in which AIRmax provides the β-cell secretory capacity.

Calfon, M. et al. IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA.

Targeted interventions in secretory vesicle trafficking by Munc18b is a novel secretion engineering strategy, which harnesses the full secretory capacity of mammalian cells.