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For all analyses we used the maximum sample sizes and replicates allowed by the software.
Using these seascape configuration metrics, patch reefs were clustered into two groups (hereafter called Fish Type I and Fish Type II for simplicity), which was sufficient to generate significant differences between groups for each seascape metric (Fig. 2A; ANOVA; P<0.05) and enabled maximum sample sizes within a group for subsequent analyses of reserve effects.
The maximum sample sizes for the current analysis were 686 in 2000 and 696 in 2010.
The maximum sample sizes were n=87 cases with OSA and n=113 healthy controls.
The maximum sample sizes obtained from such sensitivity analyses would be the conservative recommendation.
Identifying MAMS designs which maintain the overall operating characteristics but have desirable properties such as minimising the expected or maximum sample sizes is an area of ongoing research.
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Min and max are the minimum and maximum sample size across countries.
These bounds are important reference points when designing a single or multi-arm study; they are the absolute minimum and maximum sample size that would ever be required.
In other words, exact group sequential tests cannot only save the average sample size but can also save the maximum sample size when they are compared to the standard binomial test.
Second, we examine how the maximum sample size researchers are willing to collect in a main study (e.g. due to time or financial constraints) leads to overestimated effect size estimates in the studies that are performed.
If this does not happen, then the study continues until reaching a maximum sample size, n, at which point the study ends and the hypothesis of equality is accepted.
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