A comparison of the in vitro efficacy of the different β-blockers (i.e., the size of the response as compared to the isoprenaline maximum responses, taken from Table 1) and their ISA activity as judged by basal HR effects in vivo is shown in Fig. 8.
The maximum response was taken as the absolute tetanic tension.
At t = 10 s, the blue dashed line is the traveling time curve that yields the overall maximum of the array response, taking into account the signal decay.
It is not yet clear whether the average response of the tumour or the maximum response should be taken.
But quickly a response took place.
To examine this on a trial-by-trial basis, we took the maximum response in the direction opposite of the target step in each response trace to be the overshoot correction amplitude.
The response length was defined as the time interval from the time the signal reaches the maximum response to the time it took to return to the resting value.
Peak values were taken as the maximum response to the concentration of methacholine being tested, and were expressed as the percentage change relative to the saline control.
To confirm this inhibitory effect of microtubule stabilization on TRPV4 channel opening, we analysed by another parameter, i.e. the time each cell took to reach its maximum response.
It is also recognised in advanced disease that it may take many months to obtain the maximum response, but that has not as yet translated into practice for primary cancers.
