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Contractile responses are expressed as the maximum response produced by each agonist concentration.
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A basic tenet of receptor theory is that for a partial agonist the maximum response is produced only when all of the available receptors are occupied, and therefore any loss of MOPr function as would occur if receptors were desensitized would result in a decrease in the maximum response to the partial agonist.
The stimulus parameter that produces maximum response can be recovered from the timing of neural activity, i.e. its phase.
The combination of different optimized variables, which yielded the maximum response, was used to produce the gelatinolytic enzyme to verify the validity of model.
This differential effect disappeared in vessels from STZ-treated rats, where serotonin produced a maximum response of 46±7%7% (n = 12) in conduit arteries and 51±7%7% (n = 12) in resistance vessels.
This method is aimed at finding the excitation producing the maximum response from a class of allowable inputs.
Then the optimization process investigates combination of variables levels that produces the maximum response to a surface area simultaneously.
Rmax (maximum response) and EC50 (concentration to produce 50% of maximum response) values for responses to 5-HT and ACh and all other data were compared by t-test or one-way anova followed by Student Newman Keul's multiple range test as appropriate.
The estrogenic effect of a test chemical or extract on cell proliferation or luciferase activity was calculated as %RME2, a percentage of the maximum DNA/well (or the Relative Luminescence Unit, RLU) produced by the maximum response relative to 17β-estradiol (E2, positive control).
Negative logarithm of the molar concentration producing the half maximum response.
The maximum responses in each mode are then calculated from a response spectrum and these are summed by appropriate methods to produce the overall maximum response.
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