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Residual DNA in recombinant protein pharmaceuticals can potentially cause safety issues in clinical applications; thus, maximum residual limit has been established by drug safety authorities.
Results revealed detectable residues in 63.3% of 30 tested samples out of which three samples (one each of cabbage, tomato and orange samples) exceeded the codex Alimentarius maximum residual limit (0.1 mg/kg).
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The Kit detects 29 antimicrobials including beta lactams, sulphonamides, tetacyclines and aminoglycosides at and above EU maximum residual limits (MRL).
According to the Codex Alimentarius Commission regulation the maximum residual limits of oxytetracycline in muscle and liver are 200 and 600 μg/kg respectively while penicillin G should not exceed 50 μg/kg in both tissues (CAC/MRL 2015).
According to the European union and Codex Alimentarious regulation for maximum residual limits, sulfonamides should not exceed 100 μg/kg, while tetracyclines should not exceed 100 μg/kg (EUR-Lex 2010; Codex 2012).
Maximum Residue Limit.
Reference lines indicate maximum residue limit (MRL).
Maximum residue limits are set and updated periodically.
Structural relaxations were performed until the maximum residual force on each atom was <0.02 eV Å−1.
The results showed the areas of maximum residual stress.
The investigation focuses on the examination of the maximum displacements, maximum residual displacements, maximum interstorey drift ratio, maximum residual interstorey drift ratio, damage indices and ductility demands.
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