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We calculated patients' self reported daily symptom severity scores from the diary data, with scores for 13 symptoms summed and scaled to range between 0 and 100 so that the symptom severity score for a given individual on a given day could be interpreted as a percentage of maximum possible symptom severity.
The maximum possible scores for severity domains were: motor 56, non-motor 49, psychological, 49, social 28.
Finally the overall OIDP score was the sum divided by maximum possible score (5 frequency × 5 severity scores × 10 performances) and multiplied with 100 to give a percentage score.
All AC subjects in our study had a score <3 on a quantitative neurologic examination for HD (maximum possible score = 204; higher score indicates greater severity) [23] and were thus neurologically normal, and no history of musculoskeletal disease.
Several studies achieved the maximum possible score.
These three aspects: extent of disease, disease severity and subjective symptoms combine to give a maximum possible score of 103.
The cumulative score for all four paws of each rat (maximum possible score of 16) was used to represent the overall disease severity and progression.
The OIDP score is expressed as the sum of the different Performance scores (Performance score = severity score × frequency score) divided by the maximum possible score, and then multiplied by 100 to provide a percentage score.
The total OIDP scores were calculated by multiplying frequency and severity scores of each performance and then divided with the maximum possible score.
We categorised studies as high symptom severity when the mean pain and disability scores at baseline were above 60% of the maximum possible on the scale.
Thus, an overall PTSD severity score can be calculated by summing the scores for each question, which results in a maximum possible score of 68.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com