Exact(3)
The maximum possible dose was set to 27.25 mg/m.
Tissue samples were subjected to the maximum possible dose and incubation time of PK, which was just below the threshold of completely digesting the tissue specimen.
A relevant exception was the moderate (about 30%) but significant effect of yohimbine, a classical α2-adrenoceptor antagonist, administered at the maximum possible dose not inducing obvious behavioural changes (Arrant et al., 2013; Zheng and Rinaman, 2013).
Similar(57)
The top dose level was the maximum possible at the supplied concentration at a dose volume of 3 ml/kg.
The Department of Defense "concluded that their estimates of the maximum possible whole body and thyroid doses of contaminants were not severe enough to warrant further examination," Witherspoon reported.
The assumption behind the limit dose strategy is that if there are no adverse effects due to the test diet with the maximum possible level, the use of graduated doses to establish a NOAEL is unnecessary.
Comparison of IC50 doses of anticancer drugs given in vitro and their maximum possible plasma concentrations showed that in case of vinblastine the plasma concentration was much lower than the IC50 doses [ 29].
The primary efficacy endpoint was the percentage of patients showing response, defined as the achievement of at least 50%% of the maximum possible TOTPAR (≥50 % max TOTPAR), over 6 h post-dose within the respective treatment arm [3, 24].
The IC50 doses of cyclophosphamide in all of the examined cell lines were significantly lower than its maximum possible plasma concentration [ 31].
The maximum possible sentence was 5 to 15 years.
But surely three episodes was the maximum possible.
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