Administration of oxytocin and carbetocin caused similar maximum plasma concentrations of oxytocin, but onset and duration of peaks differed.
For example, after the administration of oral sumatriptan 200 mg, maximum plasma concentrations varied from 52 to 227 ng/ml in healthy volunteers [34].
GMRs (90% confidence interval [CI]) of area under curve from time zero to infinity (AUC0-inf) and maximum plasma concentrations (Cmax) of test versus reference product were 1.06 (1.03–1.10) and 1.17 (1.14–1.20), respectively.
The dose was determined by the results of our preliminary experiment and reported human data of the maximum plasma concentrations (Cmax) of oseltamivir (115 ng/mL) and Ro 64-0802 (544 ng/mL) [[6]].
Furthermore, it was reported that 30% of the abnormal behaviors of pediatric patients occurred within 2 h after the first use of oseltamivir [[9]], which is close to the time of reaching maximum plasma concentrations of oseltamivir and Ro 64-0802 [[6]].
Fingolimod's PK profile has been well described, exhibiting a high degree of oral bioavailability (approximately 93%), with maximum plasma concentrations (Cmax) usually reached 12 16 h after administration and a half-life of 6 to 9 days (David et al. 2012).
The maximum plasma concentrations of EA ranged from 2.66 to 9.38 µg/ml (8.8 30.9 µM) after i.v. administration.
Maximum plasma concentrations are dose-related.
Cmqx: colistin maximum plasma concentrations at steady state.
Cmax: colistin maximum plasma concentrations at steady state.
The maximum plasma concentrations (Cmax) and time to maximum plasma concentrations (Tmax) were determined from the highest concentration, and the time of at which it was observed.
