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Time to maximum plasma concentration occurred within the first day post-dose.
The presence of food also decreases its maximum plasma concentration (Cmax) by 38 39%.
Serial arterial blood samples were obtained at 0, 15, 30, 60, 120, and 240 min. Pharmacokinetic parameters were (mean +/- SD): Cmax (maximum plasma concentration) of 8.38 +/- 3.92 micrograms.ml-1 and Tmax (time to reach maximum plasma concentration) of 78.0 +/- 40.2 min. Our results show that 20 mg.kg-1 of acetaminophen rectally results in low plasma levels in preterm neonates.
More than three-fold increase in maximum plasma concentration (Cmax) and area-under-the curve (AUC) was observed.
In vivo, the GPO formulation had a higher maximum plasma concentration and approximately 149% (90% CI 125 179%) greater bioavailability.
For cats treated by topical application, the average eprinomectin (B1a component) maximum plasma concentration (Cmax) was 20 ng/mL.
No significant interference was observed from the tested interferents except for tetracycline at the drug's maximum plasma concentration.
Rifampin did not significantly alter the R- or S-warfarin area under the concentration-time curves (AUCs) from 0 to 12 h (period of hepatic OATP inhibition by rifampin) or the maximum plasma concentration (C max)) value.
Maximum plasma concentration.
Time to maximum plasma concentration.
Given the delayed time to maximum plasma concentration after vaginal administration this overestimates Cmax.
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