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The voxels were grouped depending on their intensity in 15 consecutive bins of increasing 6.67%% activity steps from 0%% (no activity) to 100%% (maximum pixel activity in the ROI).
The uptakes were quantified by measurements of the highest standardised uptake value - maximum pixel activity in correlation to body weight and the injected dose, grams per millilitre (standardised uptake value (SUVmax)).
At 60 min post i.v. injection, the level of [18F]FEDL in blood was 0.51±0.24%ID/ml, determined from the maximum pixel activity within the ROI placed over the heart region.
The maximum SUV (SUVmax) was recorded using the maximum pixel activity within the VOI.
The SUV was calculated using the maximum pixel activity value within the region of interest placed on the vascular wall of the transaxial PET/computed tomography image.
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Based on the reconstructed image, measure the maximum and mean recovery coefficients (RCs) of the spheres, using the following definitions: The maximum activity concentration recovery coefficient (RCmax) of a sphere is defined as the maximum pixel value within a sphere as measured on the reconstructed PET image, divided by the true FDG activity in the sphere [S true] at T a [1].
Maximum body weight-corrected standardized uptake values (SUVmax) were derived from the pixel activity within the ROI on each slice of the PET scan.
Two-dimensional region of interest (ROI) analysis was used to measure the maximum standardized uptake value (SUVmax) corresponding to each lesion, defined as the highest measured pixel activity in the ROI divided by the injected radioactivity normalized to body weight.
The SUV max was defined as the highest single maximum pixel value within the primary tumor.
R max is maximum pixel value.
CONCLUSION: SURs determined by using average pixel values provide statistically significant improvement in ROC curve areas over those determined by using maximum pixel values.
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