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The maximum peak concentration of Mn atoms is ≈22%.
The best configuration was chosen in terms of maximum peak concentration, but also in terms of economical and other practical considerations.
The initial maximum (peak) concentration (Cmax) occurs approximately 2 h post-dose.
The biopharmaceutical and pharmacokinetic parameters, i.e., maximum peak concentration (Cmax), time to reach Cmax (Tmax), area under plasma time curve (AUC) were obtained by using WinNonlin, version 6.1 (Pharsight, A Certara™ Company, USA), noncompartmental analysis.
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The maximum (peak) serum concentration (Cmax) and the area under the concentration-time curve from 0 to 24 h post-dose (AUC0-24h) were determined on Days 1 and 14, and were presented as the mean and standard deviation (SD).
A value of 1200 milliseconds was chosen to represent precontrast blood T1 (13) with a corresponding value of 100 milliseconds at maximum peak CA concentration, selected after analysis of 10 examinations within a previous quantitative study (14).
Importantly, each drug was used at the maximum peak serum concentrations achieved as reported in the literature following use for standard clinical indications.
An inverse association (p = 0.003) between the child's maximum (peak) blood lead concentration and Full-Scale IQ was apparent down to 2.1 μg/dL, the lowest measured peak concentration in our sample.
The maximum peak indoor PM2.5 concentration reported for a smoke-free setting was 239 µg/m (Wilson et al. 2011).
After ingestion, participants waited for 60 min to ensure maximum peak plasma drug concentration according to levodopa pharmacokinetics (Khor and Hsu 2007).
However, not unexpectedly, maximum peak plasma drug concentration (Cmax) was higher and the mean time to Cmax (tmax) shorter in those receiving galantamine-IR.
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