Exact(1)
Assuming the two normal distributions represent either absent or present H. pylori infection, threshold Δδ values were calculated at the maximum of specificity plus sensitivity and of negative plus positive predictive values.
Similar(59)
More importantly however, is the reliability and accuracy in misdiagnosis of a MM where current, non-histological methods, have a maximum of 87% specificity rate compared to CLSM of 98% [ 34].
We defined the ideal cut-off point by maximizing the conditional Youden score (i.e., maximum of sensitivity and specificity).
In this study, the cutoff score was selected such that it maximised the number of correctly classified tumours with and without the end point being under evaluation (maximum sensitivity with minimal loss of specificity).
However, the difference between ALL and MLL did result in a significant decrease in AUC when compared with the difference between ALL and AML (85.98 vs 95.13%, P<0.0001), which also resulted in a considerable decrease in the level of the optimal balance between sensitivity and specificity (maximum of sensitivity+specificity=154.71 vs 175.82%), as could be expected.
The bias of specificity reaches its maximum at 5.0% when specificity is 90% in one class and 60% in the other one and the number of studies is 25.
The optimal threshold value was set for each ROC curve through the Youden index (corresponding to the maximum of the sum sensitivity + specificity).
The optimal threshold value was set for each ROC curve through the Youden Index (corresponding to the maximum of the sum "sensibility + specificity").
This means that the level of the optimal balance between Type I and Type II (e.g., the maximum of the sum of the specificity and sensitivity) increases if the AUC increases.
To assure maximum specificity of ID4 mRNA detection a touchdown PCR program was designed (see additional file 1).
This level defines maximum specificity of 100%95%5% binomial exact CI: 94.5%, 100%) and can be considered a highly specific threshold level for relapse prediction.
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