If a symptom occurred more than once in any subject, durations were added, whereas severity was considered to be the maximum of the severity scores.
Total individual scores as the sum of acute and chronic parameters revealed a maximum of arthritis severity at days 13 (24.8 ± 0.6) and 21 (23.9 ± 1.4) and a subsequent decrease at day 35 (8.1 ± 1.9).
Multivariate-adjusted ORs (95% CIs) for asthma incidence, for baseline and two increasing levels of maximum severity of moisture damage (assessed by civil engineers), were 1.0, 2.8 (1.4 5.4), and 4.0 (1.6–10.2).
A current episode of disorder refers to the period of maximum severity within the episode (symptom free period not greater than two months).
C57BL/6 mice developed CIA with an incidence of 80% (eight out of 10 mice) and average maximum clinical severity of 4.1 ± 1.2.
Two different parameters were employed to measure clinical outcomes, in order to ascertain full evaluation of the effects of the various treatment regimens: i) mean arthritis scores on day 23 (the day of maximum arthritis severity); ii) area under the curve of the corresponding arthritis score curves, thus taking into consideration the whole time course of the treatment.
Maximum severity of myalgia on a scale from 0 to 10 (0 = no pain, 10 = maximum pain) [ 3, 6] was reported to be 5.7 (median, 6.0; min 0, max 10; n = 36).
Excluding those patients with hypogammaglobulinaemia at time of first rituximab, the median time to develop hypogammaglobulinaemia was 18 months (1 65), and median time to the hypogammaglobulinaemia category of maximum severity was 35 months (1 70).
11 In our material, all patients were scored at the time of maximum severity during the pre-hospital phase, in line with the recommendations suggested by Alessandrini et al.
ISR, injection site reactions Scores of dimensions and individual items of the questionnaire are presented according to maximum severity of pain in Figure 2 and maximum severity (size) of erythema in Figure 3, reported over an 8-day period (between D0 and D7).
