Sentence examples for maximum observed serum from inspiring English sources
Pharmacokinetics (PK) outcomes included trough serum concentration prior to dosing at Weeks 0, 4, 8, and 12; serum concentration at Weeks 1 and 13 (i.e. 7 days after the first and fourth doses); maximum observed serum concentration (Cmax,obs); time of maximum observed serum concentration (Tmax,obs); and terminal elimination half-life (t1/2).
The olaratumab maximum observed serum drug concentration (Cmax) following the first infusion appeared to increase with dose.
The concentration of the drugs was assessed by using a one-way analysis of variance model for dose-normalised and log-transformed maximum observed serum concentration considering the concentration-time curve (AUC).
A second primary objective was to evaluate the following pharmacokinetic parameters: the area under the curve from time zero to the time of the last measurable concentration (AUC0 last) and the maximum observed serum concentration (Cmax).
AUC0-τ,area under the concentration-time curve, estimated by using a linear/log trapezoidal method from days 1 to 28 for the first dose and days 56 to 84 for the third dose; BQL, below the quantification limit; Cmax, maximum observed serum concentration; hr, hour; IV, intravenous; n M, nanomolar; SC, subcutaneous; SD. standard deviation; Tmax, time to Cmax.
These population serum concentrations contrast with the median (447 ppt TCDD) and maximum (56,000 ppt TCDD) observed serum levels of Seveso, Italy, residents who lived near the Industrie Chimiche Meda Società Azionaria (ICMESA) 2,4,5-trichlorophenol plant when it exploded in 1976 (Needham et al. 1997/1998).
Following six biweekly SC doses of 360 mg pateclizumab, the maximum mean ± standard deviation (SD) observed serum concentration was 41.1 ± 18.4 μg/mL, and occurred on Day 74 (3 days following the sixth dose).
The maximum observed difference, in our data, between replicates is |ΔWA| = 23 (Supplementary Figure 1h).
Red areas represent the maximum observed flooding during Hurricane Harvey.
The maximum observed half-time of decrease was 26.6 s.
tmax, time at maximum observed concentration; Cmax, maximum concentration.
