Sentence examples for maximum observed concentration from inspiring English sources
The maximum observed concentration (Cmax) and the time to Cmax (tmax) were determined directly from the observed plasma concentration time profiles over the 72-h sampling interval.
Mean maximum observed concentration (Cmax) and AUC from time of dosing to time of last observation (AUC(0 t)) were calculated and expressed as a ratio (co-administration/alone). Principal efficacy end points were objective response rates, time to tumour progression (TTP) and survival.
The magnitude of the impacts is quantified by Cmax, the maximum observed concentration during release, while the time scale of the impact, τrecovery, the required time duration to recover to within (100 ± 5%) of its back ground concentration.
tmax, time at maximum observed concentration; Cmax, maximum concentration.
The maximum observed concentration (Cmax), time to reach Cmax (tmax), and last measured concentration (Clast) were obtained directly from the concentration time profile.
Although there was a dose-proportional increase in maximum observed concentration, the increase in area under the curve was more than dose proportional.
The maximum observed concentrations (C max) were 911 to 4,121 (mean 2,592) ng/mL and varied 1.4 to 14.7-fold over the pre-dose concentration (range 136 to 4,121 ng/mL; mean 445 ng/mL).
Vettorazzi et al. (2011) recently reported that administration of OTA to fasted versus fed rats resulted in increased bioavailability of OTA, and higher maximum observed concentrations in both kidney and liver, with adult male rats showing the greatest difference due to fasting.
The following pharmacokinetic (PK) parameters were determined: area under the plasma concentration-time curve from time zero up to the last quantifiable concentration (AUC0-tlast), maximum observed plasma concentration (Cmax), time of maximum observed plasma concentration (tmax).
Pharmacokinetics (PK) outcomes included trough serum concentration prior to dosing at Weeks 0, 4, 8, and 12; serum concentration at Weeks 1 and 13 (i.e. 7 days after the first and fourth doses); maximum observed serum concentration (Cmax,obs); time of maximum observed serum concentration (Tmax,obs); and terminal elimination half-life (t1/2).
The concentration of the drugs was assessed by using a one-way analysis of variance model for dose-normalised and log-transformed maximum observed serum concentration considering the concentration-time curve (AUC).
