Having applied the maximum entropy approach to network connectivity in a simulated cell signaling system, we then considered its application to a proteomic data set.
The proposed approach aims at maximum coverage under the constraints of network connectivity.
However, there are several existing studies [31, 33 35, 54] on how to set up the maximum transmission power to guarantee the network connectivity.
Such a model is obtained from information theoretic considerations by applying the principle of maximum entropy methods)[15]. Models of pairwise network connectivity obtained from entropy maximization have proven insightful in different and seemingly disparate contexts[16], [17].
The smaller the maximum number of hops, the less the communication overhead involved if the network connectivity probability is given.
In this contribution I use simplified gene network connectivity, but assume that environmental change is constant and fluctuates between a maximum and minimum through time (directional selection).
Furthermore, the IPA algorithm that generates networks will not continue if the network reaches the pre-specified maximum network size (i.e., 140 genes), which might rule out many nodes with small degrees of connectivity and impact the scale-free behavior.
"The vast majority of schools we have visited do have enough network connectivity," says Nathan.
