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The median gene maximum multiplicity score for known causal genes was 5.5; for all other genes, it was 1.0.
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Overall, genes with high gene maximum multiplicity scores were significantly more likely to be causal genes than those with lower gene maximum multiplicity scores (two-sample Kolmogorov-Smirnov test, one-tail, D34, 455 = 0.632, p < 0.05).
This relationship specifies a minimum and a maximum multiplicity.
The observed gene maximum multiplicity values for each gene ranged from 1 to 23.
(1) (2) Thus, gene maximum multiplicity is larger for genes that occur systemically across cancers.
Additional File 2 provides a gene maximum multiplicity value for each gene.
By association, other genes in clusters with high gene maximum multiplicity values are potentially driver genes.
The simpler one-dimensional measure, gene maximum multiplicity alone, provides none of this information.
The cancer maximum multiplicity values of the cancers range from 4 to 53.
Genes with higher gene maximum multiplicity values will cluster more tightly on the central axis.
Given cancer maximum multiplicity derived distances, a hierarchical clustering technique is used to generate meaningful clusters.
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