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We found that AEA was reduced in the spinal cord at the time of maximum mechanical hypersensitivity following paw incision (postoperative days 1 and 3) and returned to basal levels by the time paw incision-induced allodynia had spontaneously resolved (postoperative days 9 and 15).
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DOI: http://dx.doi.org/10.7554/eLife.12002.007 Next, we investigated the molecular and cellular mechanisms underlying the mechanical hypersensitivity of Eif4ebp1-/ mice.
Thermal hypersensitivity occurred earlier than mechanical hypersensitivity in rats following CCI, and HBO treatment effectively reduced both hypersensitivities.
The inflammatory pain behaviors induced by venom of Chinese scorpion Buthus martensi Karsch (BmK) include spontaneous pain, ipsilateral thermal hypersensitivity, and bilateral mechanical hypersensitivity in rats [1, 2].
Furthermore, we found that intrathecal injection of desCER induces mechanical hypersensitivity in a dose dependent manner.
In addition, spread of mechanical hypersensitivity beyond the facial region was noted.
SCC animals displayed increased escape/avoidance behavior postinjury, indicating at-level mechanical hypersensitivity.
Basal and nitroglycerin-evoked mechanical hypersensitivity was evaluated using manual von Frey hair stimulation of the hindpaw.
Previously we have reported that BmK I induced a mirror-image mechanical hypersensitivity where injection of BmK I at one side of hind paws caused mechanical hypersensitivity on both sides of hind paws.
Development of significant mechanical hypersensitivity was observed in CCI rats after postoperative day 4 (P < 0.05 vs. sham) and heat hypersensitivity developed after postoperative day 2 (P < 0.05 vs. sham).
Behavioral testing showed that, while thermal sensitivity was unaffected, mice depleted of Langerhans cells displayed mechanical hypersensitivity.
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