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It reflects a maximum limit tolerated by passengers.
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The limits of detection and quantification (below 30 and 100 μg L−1, respectively) were in all cases lower than the maximum residue limits tolerated for these compounds in milk.
Celiac disease patients administered fixed intradermal doses of Nexvax2 become unresponsive to the HLA-DQ2·5-restricted gluten epitopes in Nexvax2, but gastrointestinal symptoms and cytokine release mimicking gluten exposure, that accompany the first dose, limit the maximum tolerated dose to 150 μg.
Now the maximum limit is 75mph.
The maximum limit is six.
In phase I trial were tested in children with solid tumours to establish the dose limiting toxicity and maximum tolerated dose [292].
Patients were recruited as specified in the protocol: "A Phase I Clinical Trial to Evaluate Dose Limiting Toxicity and Maximum Tolerated Dose of Intralesional Administration of REOLYSIN for the Treatment of Histologically Confirmed Malignancies".
To determine the dose-limiting toxicity (DLT), maximum tolerated dose, recommended dose (RD) and preliminary evidence of activity of escalating doses of irinotecan (CPT-11) fixed-dose-rate infusional gemcitabine (FDR-GMB) and bevacizumab in pretreated metastatic colorectal cancer (mCRC) patients.
Etoposide was administered intravenously on day 2 in a dose of 150-250 mg m-2 and orally 150-300 mg twice daily on days 3 and 4. Cardiovascular effects of nifedipine were dose limiting and the maximum tolerated dose was 60 mg bid.
Diarrhoea was the dose-limiting toxicity at a maximum tolerated dose of 320 mg once daily.
There were no dose-limiting toxicities, so the maximum tolerated dose was not reached.
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