COPASI provides, in addition to the best parameter set, standard deviation of the parameter estimates assuming a maximum-likelihood statistics, which in effect expands a quadratic surface of the sum-of-squares fit criterion around the optimal fit.
The present study also employs a cointegration technique using maximum likelihood test statistics.
Variance components were estimated and restricted maximum likelihood test statistics were calculated at the midpoint of each marker interval.
A classic result on coherent detection for the frame synchronization has been presented by Massey [1], which suggests the usage of a data correction term for the optimal maximum likelihood (ML) statistics.
Odds ratios (OR) and 95% confidence intervals (CI) were estimated for main effects from maximum likelihood regression statistics.
Forward and backward stepwise logistic regression using maximum likelihood-ratio statistics were used for further support of variable selection.
There are now sophisticated methods available using Bayesian (Drummond et al. 2006; Thorne and Kishino 2002; Thorne et al. 1998) or maximum likelihood (Sanderson 1997) statistics to deal with changes in the rate of evolution amongst lineages when estimating divergence times.
The use of the probability peaks to determine the time at which each cell multigenic configuration is most probable follows the standard reasoning in deriving maximum likelihood estimators in statistics [25].
Routines that facilitate calculation of some simple maximum likelihood and resampling statistics are supported as well.
