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The maximum lifespan and age at sexual maturation of cynomolgus monkeys are 27 years and 3 years respectively [24].
Lifespan parameters included average, median, and maximum lifespan and reduced mortality.
The model included CD33rSiglec gene numbers as response, maximum lifespan and body mass as covariates.
Maximum lifespan and average adult body weight were retrieved from the AnAge database.
The full equation (2.3 a) can be seen as (2.4), corrected for maximum lifespan and population growth.
Overall, a positive correlation was shown between the residual maximum lifespan and residual CD33rSIGLEC gene numbers (controlling for both body mass and phylogeny).
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x ¯ ± Δ m mean lifespan and standard error of the mean; M – median lifespan; 90 % – age of 90%% mortality; Min and Max – minimum and maximum lifespan; α and R 0 – Gompertz equation parameters; MRDT – mortality rate doubling time (ln2/α); n — sample size; +PDTC −PDTC treatment; −PDTC – without PDTC treatment.
In addition to one member of the glutamate class that acts on a glutamate-gated ion channel [the NMDA receptor (+16% lifespan increase)], targets of these compounds include calcium (25% maximum lifespan increase) and potassium channels (42% maximum lifespan increase).
We used three levels of adult nutrition that were predicted to induce different life-history phenotypes, but not to cause extreme stress [ 28] (optimal food – maximum lifespan, malnutrition and overfeeding exerted negative lifespan effects; Figure 1).
For each experiment, we calculated the following parameters: mean lifespan, median lifespan, minimum and maximum lifespan, lifespan lower and upper quartiles, lifespan of the 10th and 90th percentiles; variance, standard deviation, and standard error for the mean lifespan (Table 1).
In our study, the anticonvulsive lamotrigine increased mean and maximum lifespan in male and female Drosophila, but compromised the fly health span, as revealed by a significant decrease in locomotion and a trend towards a depression in metabolic rate.
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