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At dose level 6, the maximum level tested, six patients were enrolled and no DLT was reported.
In most cases, no measurable ABR responses were detected at the maximum level tested (90 dB peSPL).
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Overall, 22 patients were treated at the maximum dose level tested.> -wrap-foot> dose-limitingitoxicityicitoxicity
When the response cannot be detected at 95 dB SPL, threshold was arbitrarily assigned to be 95 dB SPL, the maximum sound level tested at King's College London.
On days 1 and 5, at the maximum dose level tested, the azacitidine Cmax was 581 and 638 ng/ml, the t1/2 was 0.67 and 0.42 h, the clearance was 178 and 156 l/h/m, the volume of distribution was 121 and 94 l/m, and the AUC0-inf was 412 and 432 h-ng/ml, respectively.> -wrap-foot> aMedian = 259.2.
At the maximum dose level tested, the oxaliplatin Cmax was 650 ng/ml, the t1/2 was 16.5 h, the clearance was 24.5 l/h/m, the volume of distribution was 554 l/m, and the AUC0-inf was 1,456 h-ng/ml.> -wrap-foot> C max, maximum concentration; AUC, area under the curve; t 1/2, half-life of elimination; V d, volume of distribution; CL, clearance.
The cultures were not photoinhibited even under the maximum irradiance-level tested (2500 μE m−2 s−1).
On Sunday, a test a mile north showed 1,150 times the maximum level, and a test the day before showed 1,250 times the limit in seawater taken from a monitoring station at the plant.
By creating a distribution from 100 random sets of permutation, statistical significance (p < 0.05) was estimated as the proportion of elements in the randomization null distribution exceeding the observed maximum-cluster level test statistics.
During the second half, they will train at one level below their maximum tested level.
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