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Hind limbs were harvested at sacrifice (day 28) and scored by radiographic joint index on a scale from 0 to 3, based on soft tissue swelling, joint space narrowing, periosteal new bone formation, and presence of erosions and/or ankylosis (0 = normal; 3 = maximum joint destruction).
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The tissue-destructive inflammation affects all joint structures, leading eventually to total joint destruction.
R.A. has significant health consequences beyond joint destruction.
Joint pathogenesis involves inflammation of the synovial lining, with the potential to cause joint destruction.
As in periprosthetic joint infection of the shoulder, it can lead to joint destruction, extreme pain, and severe functional impairment.
Rheumatoid arthritis (RA) is a chronic heterogeneous autoimmune disease characterized by progressive joint destruction.
Synovitis, which is secondarily induced, is related to joint destruction and OA progression [19].
In latter stages joint destruction, bone union and malalignment may occur (Fig. 2).
Joint arthrodesis is recommended in generally ill patients even with mild joint destruction for early assisted mobilisation as well as in patients with chronic joint affection (Fig. 5).
FGF8 induced joint destruction in vivo.
Repeat injections enhance chronicity and joint destruction.
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