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It was notable there was a delay in the initial rate of internalization by the hIPΔ312 in the presence of exogenous Rab5a (Fig. 6B) relative to that observed in its absence (Fig. 6A), where maximum internalization was achieved at 90 min in the former (Fig. 6B), compared to 60 min for the latter (Fig. 6A).
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For the 180-μg-dose data, the average maximum internalization rate is 1.2 × 1013 molecules per gram of tissue per hour.
Cell internalization was studied by flow cytometry and confocal microscopy.
The detrimental biological consequence accompanied by cell internalization was limited.
Internalization was related to children's externalizing behavior problems.
In vitro internalization was determined using glioblastoma C6 cells.
BCR internalization was reduced in LAB/NTAL-deficient murine B cells, suggesting a regulatory role for LAB/NTAL in activation-induced internalization of the BCR.
This internalization was temperature-dependent.
Ligand internalization was performed as previously reported [17].
The internalization was also confirmed by Western blot (Fig. 4B).
Receptor internalization was determined on fixed permeabilized specimens as follows.
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