Half-maximum inhibitory concentration.
Data thus obtained are used to quantify the half-maximum inhibitory concentration (IC50) of the non-labelled ligand [2].
One newly synthesized derivative exhibited a remarkably strong activity, with a half-maximum inhibitory concentration value (IC50) of 65 pM.
In our study, only bioassays containing both assay information of half-maximum inhibitory concentration (IC50), half-maximum effective concentration (EC50) or Ki values, and the explicit target sequence (GI) were systematically extracted from PubChem Bioassay database.
The ability of the complexes to inhibit carcinoma cells growth was assessed by determining their IC50 values (half-maximum inhibitory concentration) in three different human carcinoma cell lines: HeLa (cervix-uterine), PC3 (prostate), and HCT-15 (colon).
The concentration response relationships were fitted to evaluate the half-maximum inhibitory concentration (Fig. 2C).
We have determined that progesterone's half-maximum inhibitory concentration (IC50) for hKSper is 7.5 ± 1.3 μM.
Dose-ranging studies of -JQ1 demonstrated potent inhibition of H4Kac4 binding with a half-maximum inhibitory concentration (IC50) value of 10 nM for murine BRDT(1) and 11 nM for human BRDT(1).
The half-maximum inhibitory concentration (IC50) for each probe was determined by fitting the data using KaleidaGraph (v 4.1.1, Synergy Software) and the dissociation constant (K i ) calculated using an online K i calculator (Methods).
Bioactive components from the leaves of L.obtusiloba described so far exert cytotoxicity against tumors as shown with human cancer cell lines from lung (A549), ovarian cancer (SK-OV-3), skin (SK-MEL-2), the central nervous system (XF498) or colon (HCT15) with half-maximum inhibitory concentration (IC50) values ranging from 3-20 μg/ml of the respective compounds [ 29, 30].
The half-maximum inhibitory concentrations (IC50) have been determined for 4-hydroxytamoxifen, BPA-C, 2,2-bis(4-hydroxyphenyl) propane A, BPA-A, and other derivatives.
