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Because the difference of EC50 or EC20 values among PFHxI, PFOI, and PFBDI were small, we compared the estrogenic potency with the maximum induction value in an MVLN assay.
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PFHxI (EC20 = 14.1 μM) showed higher estrogenic activity than did PFOI (EC20 = 20.4 μM) in MVLN cells, with maximum induction values of 47% and 25%, respectively (Table 2).
PFHxDI (EC20 = 0.38 μM) showed stronger estrogenic potency than did PFODI (EC20 = 1.07 μM) and PFBDI (EC20 = 13.8 μM), with the maximum induction values of 73%, 38%, and 21%, respectively.
PbGR2b showed a significantly greater binding affinity for H-dexamethasone than PbGR1, as reflected by lower values of Kd, and this observation coincided with a significant difference in the EC50 and maximum fold induction values of the hormone in the transactivation assay (Table 2).
The formation temperature, maximum induction temperature and induction time are measured.
Besides maximum induction, in one case we induced using 5% of the concentrations needed for maximum induction (weak induction), and in another with 15% (medium induction).
Under maximum induction, the average production was 4 RNA/h.
The table shows the p-values of the enrichment of the module's putative targets within the top 10% targets of NF-κB/ISRE, based on the genes' maximum induction (across all time-points) in response to LPS.
Induction of mRNA expression in HAEC (maximum induction: 25·3 ± 0·9; P < 0·05) and HPAEC (maximum induction: 22·5 ± 2·6; P < 0·05) was significantly higher than that in HUVEC (maximum induction: 9·1 ± 3·1); induction in HLMVEC (maximum induction: 20·1 ± 8·9) maintained this tendency (Fig. 3c).
Here, genes were ranked based on their maximum induction in response to LPS.
Maximum induction of nSLO-LA by LPS (100 ng/mL) occurred between 4 and 6 h).
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