As a rule, the higher the background luminescence the lower the maximum induction of the sensors (Tables 1, 2, 3, 4).
Characteristics (number of cells in the test, background luminescence, maximum induction) of the constructed sensors are presented in Table 1.
We demonstrate that optimal growth does not coincide with maximum induction of the mar promoter, but instead results from the interplay between drug toxicity and mar induction.
Our analysis provides a quantitative description of the MAR system and demonstrates that optimal cell growth in the presence of an inducer and an antibiotic does not coincide with maximum induction of the mar promoter, but instead results from the interplay between drug toxicity and mar induction.
As the fraction of TCDD in the liver increases from 15 to 70%, there is a 5-fold maximum induction of the elimination rate in rats.
ALP showed maximum induction in the differentiated control cells at 9 days, with an increase of 167 ± 32% (p ≤ 0.001) relative to undifferentiated control.
This suggests that although rhTRAIL mostly signals via DR4, both DR4 and DR5 might be important for maximum induction of the apoptotic signal using rhTRAIL.
This higher dose was chosen in an attempt to ascertain the maximum induction of FXN within the limits of dyclonine solubility.
A group of 25 genes functionally linked to apoptotic pathways showed a coregulated expression pattern with the T cell response gene set, and was assumed to be involved in controlling cell death of T lymphocytes and/or host target cells, as their maximum induction coincided with the histopathology peak.
Although lower maximum induction was observed, the alkylphenols nNP and nOP alone also elicited a clearly significant estrogenic response in the concentration range of 10−8 M to 10−5 M and 10−6 M to 10−5 M, respectively, with EC50 values of 8.9 μM and 4.9 μM, respectively.
