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RNR1 and RNR3 are also achieve maximum induction by γ-ray at the highest dose, but were excluded from this clustering analysis by statistical filtering.

This data shown in Figure 3A indicates that gene expression is increased by 8 hours and reaches maximum induction by 24 hours.

Firefly luciferase activity in each well was normalized to protein amount and the resulting ratio expressed as a percent of maximum induction by E2 (10 nM).

Emodin was also evaluated in ER-transfected SKBR3 cells; maximum induction by emodin was significantly greater than that of E2 in ERα-transfected but not ERβ-transfected SKBR3 cells with 141 ± 12% and 127 ± 26% of maximum E2 activity, respectively.

The time course of gene induction demonstrated for four independent Panc02+RHeoSwitch+luciferase cell clones each showed an increase within 12 hours of GS-E treatment and reached the maximum induction by 24 hours.

Similar(55)

Maximum induction of nSLO-LA by LPS (100 ng/mL) occurred between 4 and 6 h).

EE induced UWW increases only at 24 and 72 hrs in the mouse, while in the rat the classic water imbibition response occurred between 4 and 12 hrs followed by maximum induction at 72 hrs.

Similarly, the maximum induction of ER-mediated genes by quercetin for ER-α and ER-β were 1.7 and 4.5 times greater than those reached by E2 (van der Woude et al. 2005).

Maximum induction of primary-response genes by 20E is expected to occur after 4 hours of exposure to the hormone, however, some secondary-response gene transcription may have already begun at this point [ 1, 4].

A higher IPTG concentration was needed to achieve maximum induction, possibly due to the tighter DNA binding exhibited by lacI W220F.

Maximum induction of these genes occurred at 12 hpi and was followed by relatively constant expression.

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