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Curated information for keratinocyte activation included the maximum fold induction of luciferase activity (Imax), concentrations for the n-fold induction of luciferase (EC1.5, EC2, and EC3) and cytotoxicity (IC50).
A similar but quantitatively smaller increase was observed when the fluorescent receptor construct, GHR GFP, was substituted for the wtGHR (maximum fold induction 6.5±0.9, Figure 3A).
Maximum fold induction (10-fold) was at day 8 and was followed by a slow decline to values closely resembling control at the last time point.
PbGR2b showed a significantly greater binding affinity for H-dexamethasone than PbGR1, as reflected by lower values of Kd, and this observation coincided with a significant difference in the EC50 and maximum fold induction values of the hormone in the transactivation assay (Table 2).
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Interestingly, at 37°C there is no difference in AHL-dependent maximum fold-induction between growth in motility agar (Figure 6) or liquid broth (Figure 8).
In our study, there was a higher maximum fold-induction of HSP90α transcripts compared to HSP70-1 transcrints in both liver and muscle following heat-shock.
For each gene, the tables indicate (the log2 of) its maximum fold-induction (over all time-points) in response to LPS in all four datasets, as well as its kinetic pattern (in case of conflicting patterns in different datasets, the default pattern is in MmBMM, * is in MmRAW, and ** is in HsM1).
Phthalate monoester metabolite concentrations required to activate human PPARα are two to three times higher than the concentrations required to activate mouse PPARα, and the maximum-fold induction is less for human PPARα than for mouse PPARα (Bility et al. 2004; Hurst and Waxman 2003; Maloney and Waxman 1999).
After 120 h of treatment with 900 μM Ribavirin followed by 12 h treatment with 10 μM SAHA the increase of ESR1 mRNA induction reached a maximum 276 fold induction [cf. additional file 4].
The model assumes a maximum 40-fold induction of CYP1A2, resulting in estimates of KBILE_LI from 0.06 to 2.46 hr−1 at exposures from 10−3 to 10 μg/kg.
In the case of DHN2 transcripts, expression reached a maximum 5-fold induction compared to baseline levels 4 h after application of ABA.
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