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Additionally, the present study revealed novel genes, e.g. the unknown gene (LOC_Os01g40290), that showed maximum fold change in microarray analyses results.
In addition, we also found that the gene encoding CD24/HSA had the maximum fold change among the down regulated genes.
A more important reason that none of these examples would be excluded by the criteria used by de Jonge et al. is their interpretation of the maximum fold change (MFC).
A candidate housekeeping gene was defined as a gene with the most stable expression, i.e. a gene with a small coefficient of variation (CV) and a maximum fold change <2 (MFC, the ratio of the maximum and minimum values observed within the dataset).
As a result, a list of 15 genes was suggested with the most constant expression level, based on a coefficient of variation smaller than 4%, a maximum fold change smaller than 2 and a mean expression level lower than the maximum expression level minus 2 times the standard deviation.
We used the 48 genes with maximum fold change in that list.
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In both kidney cortex (Fig. 5a) and liver (Fig. 5c), the single detected gene (Iap and Cyp7A1, respectively) was up-regulated at all times of day with a maximum fold-change at 12 00.
The maximum fold-change in IC50 for any drug was not representative of the drug's dynamic range.
The maximum fold-change in IC50 varied even more dramatically, ranging from approximately 13 for d4T to more than 43,000 for EFV.
Maximum fold-change, defined as the ratio of the maximum and minimum hybridization signal values, was calculated for each sequence.
Duplication of genes in the DEG datasets was resolved by selecting the gene with the maximum fold-change value [ 56].
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maximum velocity change
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