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These neurons showed adaptation during repetitive firing and lower maximum firing frequencies (Fig. 5f).
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Electrical stimuli excite smaller fibers at lower frequencies because the maximum firing frequency is lowest for these fibers [17].
Place field size is computed as the region of the arena in which the firing rate of the place cell is above 20% of the maximum firing frequency (Hollup et al., 2001).
The effects of rapid AIS shortening were much clearer on repetitive spike firing in pro PKA conditions, where 3 hr depolarization produced a significant decrease in the DGC input-output function with a significant reduction in maximum firing frequency.
In response to a strong depolarizing current injection, the maximum instantaneous firing frequency was observed between the first and the second spikes, reaching a value of more than 50 Hz.
In previous studies on cortical interneurons, one of the most frequently used electrophysiological parameter for defining interneuron types is the maximum AP firing frequency, Fmax (e.g., Kawaguchi and Kubota 1997; Gibson et al. 1999; Sun et al. 2006; Gentet et al. 2010; for a review, see Ascoli et al. 2008; Gentet 2012).
The unit best frequency (BF), or the frequency that produced the maximum firing rate, was defined by the frequency with the lowest threshold in the 0.9 criterion iso-response curve.
As the frequency of a firing neuron cannot be infinite, the maximum firing rate is limited, and thus, the membrane potential is normalized.
Thus, firing frequencies in motor neurons control the chromatic pattern.
The maximum firing rate decreased from 79 to 17 spikes/s.
(D ) The time varying firing rates scheme exhibits a clear onset time and a different maximum firing rate for each neuron.
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