Sentence examples for maximum feasible dose from inspiring English sources

Dose escalation proceeded without dose-limiting toxicities to a maximum feasible dose of 3 × 109 pfu.

Typically, use of the term "high dose" reflects a consideration of a Maximum Tolerated Dose (MTD) or a Maximum Feasible Dose (MFD), inexact terms applied to the design of nonclinical studies conducted to support human clinical trials for experimental new drugs.

The highest dose (180 mg) was considered the maximum feasible dose and was not expected to exceed previously tested and safe exposure levels.

The RP2D was the maximum feasible dose of 20 mg kg 1 of figitumumab in combination with 75 mg m 2 of docetaxel.

Based on the MBMA results of the marketed compounds, the G/NG criteria were defined as a 50% point improvement from placebo response at the maximum feasible dose.

In conclusion, the combination of figitumumab at a maximum feasible dose of 20 mg kg 1 and docetaxel at 75 mg m 2 is safe and well tolerated in patients with advanced cancer, with no substantial alteration in the PKs of either agent.

No dose-limiting toxicities (DLTs) were observed in these phase I studies, in which the maximum tolerated dose (MTD) was not reached, and the maximal feasible dose and recommended phase II dose (RP2D) was 20 mg kg 1 every 3 or 4 weeks (Haluska et al, 2007; Lacy et al, 2008).

The relative inability of conventional radiotherapy to control localized prostate cancer results from resistance of subpopulations of tumor clonogens to dose levels of 65 to 70 Gy, the maximum feasible with traditional two-dimensional (2D) treatment planning and delivery techniques.

Instead, it tells the air resources board to come up with a plan for the "maximum feasible reduction" in emissions.

Conservatives should want a smaller welfare state than liberals in order to uphold maximum feasible individual liberty and responsibility.

Some in the Housing Authority shared wholeheartedly the Great Society credo of "maximum feasible participation," in which dignity and self-assertion were as important as any brick and mortar undertaking.