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At day 4, higher epithelial CD8+ cell counts in subjects with asthma were significantly associated with a greater maximum fall in FEV1 (percent fall from baseline) (r = −0.72, P =.03) (Fig 6A).
No clinically important falls in haemoglobin were seen in either group, with the maximum fall in haemoglobin from baseline being 1.4 g/dL in the hookworm group and 0.8 g/dL in the placebo group.
Although aerosolized acetaldehyde-induced bronchoconstriction was significantly prevented by ozagrel, there were no differences in the time course of the decrease in PEF or the maximum fall in PEF after alcohol intake between placebo and ozagrel.
The EIB+ group had a slightly lower methacholine PC20 than the EIB− group (P = 0.01), resulting in a modest relationship between the maximum fall in FEV1 after exercise challenge and the methacholine PC20 (r2 = 0.43, P = 0.01).
The degree of protection provided by montelukast on hyperpnea-induced bronchoconstriction in the present study is similar in magnitude to previous reports using an exercise challenge [11], [12], which have shown that 2-hr following a single 10-mg dose of montelukast the maximum fall in post-exercise FEV1 was reduced by approximately 52% [11] and 33% [12] compared to placebo treatment.
Maximum fall in the systolic blood pressure was noticed after 25 minutes in all the groups.
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The absorption maximum of 6-HQ in polymer films was observed at 333 ± 1 nm, whereas fluorescence (FL) maximum fell in the range of 365 371 nm.
The maximum falls in blood pressure at any time during or in the two hours after infusion were also assessed.
Additionally, the subjects with asthma with high epithelial CD8+ counts had significantly greater maximum falls in FEV1.
We reported before that asthmatic patients showed significantly higher total chest symptom score, significantly higher maximum falls in FEV1 and PEF, and significantly lower PC10 values at baseline, day 6, and week 6 compared with healthy controls [ 5].
The isolated compounds 1 and 2 at a dose of 50 mg/kg b.w., produced the maximum fall of 83% in the blood glucose level in the diabetic rats after 3 h of the treatment.
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