These doses are well above the maximum estimated alveolar dose of 0.001 μg cm−2 for a worker breathing at a rate of 1 m hr−1 at the ACGIH recommended threshold limit value for silver of 0.1 mg m−3, assuming a fraction depositing in the alveolar region of 0.3 and an alveolar surface area of 75 m.
The Stone's Poisson maximum test is based on the maximum value of the SIR as ' communes' ranked by increasing estimated dose are aggregated into a region of greater size (Stone, 1988).
The linear risk score test and Stone's Poisson maximum test explicitly investigate for an increase in SIR with increasing estimated dose.
Short-term treatment with furan at a dose approaching the maximum estimated human dietary intake resulted in reversible changes in the expression of genes that control the cell cycle and cell death but did not appear to influence the expression of genes involved in responses to DNA damage.
The maximum estimates of dose due to fallout are 0.01 0.03 Gy in Hiroshima and 0.2 0.4 Gy in Nagasaki.
To investigate whether germline pathological mutations most strongly affect CBC risk in women who had highest levels of RT (women were received a dose of 30 to 76 Gy), we compared the estimated maximum radiation dose to the contralateral breast with the estimated radiation dose at the site of the tumour in the contralateral breast between mutation carriers and non-carriers.
Both the chemotherapeutic drugs and AQ4N are given at doses which individually are close to their estimated maximum tolerated dose (data not included) which provides indirect evidence that in the combination chemotherapy experiments there is some tumour selectivity in the enhanced action of the drugs.
Estimated maximum tolerable doses and fractionally lower doses of each compound were administered to groups of 50 male and 50 female rats and mice for 2 years, followed by sacrifice, necropsy, and histopathological examination of major organs and tissues.
More specifically, many such designs are now 'seamless' in nature, meaning that, in addition to estimating a maximum tolerated dose, initial efficacy estimates at this dose level in one or more subpopulation are sought.
The geometric mean (GM) concentration was 3 ppb, the maximum value was 233 ppb, and the highest estimated systemic dose was 0.004 mg/kg.
