Exact(1)
The maximum estimated concentration of WNV in human blood tested during screening of blood donors in 2002 was approximately 103.2 PFU/mL (S. Stramer, M. Busch, M. Strong, pers. comm).. Thus, it appears unlikely that humans exhibit WNV viremia levels of sufficient magnitude to infect mosquitoes.
Similar(59)
The maximum estimated 1-hr concentration exceeded 1500 nmole/m3 for H+ ions.
The maximum estimated portal vein concentration (up to 45 µmol/l) exceeded the IC50 for 99mTc mebrofenin uptake in human SCH (~3.5 µmol/l).
The maximum estimated increase was 461 calls.
Thus, these mentioned values represent maximum estimates for sperm concentration.
Results from a phase 1 study of IV panobinostat in patients with refractory hematologic tumors demonstrated an approximate proportional increase in plasma concentration and drug exposure, with an estimated maximum concentration (Cmax, mean ± SD) of 565.6 ± 450.9 ng/mL at the highest dose administered (14 mg/m) [ 6].
Observed concentrations of tetracycline, epi-tetracycline, chlortetracycline, iso-chlortetracycline, epi-so-chlortetracycline, lincomycin, and trimethoprim were at least 1 order of magnitude smaller than the theoretical maximum concentration estimated for lagoon water (Table 1, 2).
Figure 3 shows distributions of the estimated maximum hourly concentration for the homes simulated as well as estimated maximum hourly exposure concentrations for the occupants simulated.
The pharmacokinetic parameters estimated were maximum plasma concentration (C max), half-life (T 1/2), the area under the plasma concentration-time curve (AUC), and the mean residence time (MRT).
The drug levels from blood collected 2 hours after medication administration (C2hr) were used as the estimated peak maximum serum concentration (Cmax) as per standard practice and were determined by using high-performance liquid chromatography (for isoniazid and rifampin) or gas chromatography with mass spectrometry (for ethambutol and pyrazinamide).
For comparison, the minima and maxima of the measured and estimated PM10 concentrations from both regular and log-normal ordinary krigings are also listed in Table 4.
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