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Therefore, clinicians may need to utilize different opioids to achieve maximum efficacy for each patient.
In many ways, the experience that accompanies and shapes a therapy promoting neuroplasticity is akin to the common practice of adding an adjuvant (such as a carrier protein) to achieve maximum efficacy for many vaccines.
The maximum efficacy for targeted agents occurs below toxic doses, allowing both gefitinib and cetuximab to be administered at doses lower than the MTD to maximise the benefit : risk ratio.
Provided that pathogens can also counter suicide mechanisms by inhibiting them or delaying their effect [ 6, 53], it seems appropriate to include a maximum efficacy for suicide which limits the probability of successful suicide even if the suicide propensity is equal to one.
Similarly, administration of the anti-CD20 agent, rituximab, led to a significant improvement in HDL cholesterol levels and macrovascular endothelial-dependent function after 16 weeks [ 37] and 24 weeks of treatment [ 40], both of which are time points associated with maximum efficacy for rituximab in reducing inflammation [ 41].
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Studies in mice also suggest that it would be crucial to deliver the normal gene before maturation of the photoreceptors for maximum efficacy of treatment rather than delivering the gene after maturation (Byrne et al., 2014).
The maximum efficacy of the PEF treatment for inactivation of microorganisms in grape juice was observed around 1500 MJ L− 1 for all the microorganisms investigated.
However, to reach the maximum efficacy of the Xe2*-excilamp for photo-initiated water purification further engineering optimization of the photoreactor concept is necessary.
Although 131I-MIBG is associated with therapeutic success in the form of long-term remissions and palliation, it is likely that for maximum efficacy, there is a requirement for this radiopharmaceutical to be administered in combination with other chemotherapeutic agents [2].
Good adhesion of the fentanyl patch to the skin is essential for maximum efficacy, therefore patients must be instructed on the proper technique for patch application [ 30].
Monotherapies are cheaper to make, particularly as they often come as five-day courses rather than the seven needed for maximum efficacy.
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