Sentence examples for maximum efficacious from inspiring English sources

However, this differentiation diminishes at the maximum efficacious dose.

This combination may only be suitable to test drug candidates for side effect profiles at partially efficacious levels but not the maximum efficacious levels.

Overall, the efficacy and side effect profiles of the two compounds exhibited differentiation at low to mid doses (0.03 0.1 mg ciclesonide, 0.01 0.03 mg fluticasone), while this differentiation diminished at the maximum efficacious dose (0.3 mg ciclesonide, 0.1 mg fluticasone), likely due to overdosing in this model.

However, it is only suitable at sub-maximum efficacious levels.

Clinical evidence demonstrates coadministration of tumour necrosis factor inhibitor (TNFi) agents and methotrexate (MTX) is more efficacious than administration of TNFi agents alone in patients with rheumatoid arthritis, leading to the perception that coadministration of MTX with all biologic agents or oral disease-modifying antirheumatic drugs is necessary for maximum efficacy.

The latter has usually been taken as the mean unbound efficacious maximum plasma concentration.

We have also carried out in vitro and in vivo studies of Bi-PAI2 for prostate cancer (Li et al, 2002b), finding it to be efficacious within the maximum tolerance dose limits.

An "answerable" research option may lead to an "efficacious and effective" intervention; "maximum disease burden reduction" may lead to "equity", etc.

It was found to be efficacious at 1/10th the maximum-tolerated dose (1000 mg/kg) against human tumours derived from HCT-116 (colon) and NCI-H460 (lung) cells in SCID (severe-combined immunodeficient) mice models.

The developed solutions, which leverage the maximum principle and dynamic programming, are shown to be efficacious in controlling the LIF models.

T14 and T30 were equally efficacious at the high affinity site, with maximum displacement at about 45% of total specific binding, however T30 (Ki = 16.8±1.8 pM) displayed much greater potency than T14 (Ki = 653.3±12.6 pM).