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Effects on protein synthesis became visible after two hours of digitoxin treatment whereas maximum effects were achieved after 4 hours (Figure 3b).
Maximum effects were observed after 12 months (35).
Maximum effects were observed after 30 min (c-fos, c-jun, signalling kinases) to 2 h (COX-2, signalling kinases).
In all the three Chinese cities, the maximum effects always occurred at lag 0 1 days, except for O3 in Shanghai, where maximum effects were recorded at longer lags.
Moreover, this day profile in a real-life situation is consistent with the mean plasma concentration of Equasym XL®, which shows a peak 6 h after ingestion [ 20]; it is also in line with the pharmacodynamic profile across the day in a laboratory classroom situation described in the COMACS study [ 42], in which maximum effects were observed 1.5 6 h after administration.
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Possible explanations for this might be that the maximum effects are reached with one of the miRNAs and adding another does not increase the effects.
For most drugs, maximum effects are probably achieved initially.
The minimum and the maximum effects are given between square brackets; (3 Number of significant parents.
This review attempts to determine, from published studies, the time-course of the effects induced by testosterone replacement therapy from their first manifestation until maximum effects are attained.
It can be concluded that the effects of testosterone on muscle strength are demonstrable after 12 20 weeks and that depending on the achieved testosterone levels, the maximum effects are attained after 6 or 12 months.
The IC50 values for the Cell Number endpoint, the concentrations corresponding to 50% of the maximum effect, were determined by linear regression on the most linear portions of the curves where toxic effect occurred for each toxicant.
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