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Half maximum effective concentration (EC50) value for ZnO NPs was found to be 38.44 µg/ml and that of modified ZnO NPs to be 55.24 µg/ml for MDA-MB-231.
From the result of fluorescence spectrophotometer, the EC50 of Troglitazone was 0.496 µM, and the maximum effective concentration was 10 µM.
In this assay, the data from fluorescence spectrophotometer displayed a dose-dependent manner of CHIR99021, with the EC50 of around 206 nM, and the maximum effective concentration was 1 µM (Fig. 3g, 3i).
At the dosage employed in our current studies (10 mg/kg, with a maximum effective concentration of around 25 µM), TRA is likely to profoundly antagonize 5-HT2 receptors but only modestly affect T-type channels [40], [47].
Additionally, from the data of fluorescence spectrophotometer, we found that the inhibition effect of LY294002 acted in a dose-dependent manner, with the effective concentration for half-maximum response (EC50) of 15 µM and the maximum effective concentration of 40 µM.
Using a maximum effective concentration model, neutropenia was proportional to exposure.
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Some medications may possess dose-limiting systemic side effects that hinder their ability to reach maximum effective concentrations in the CNS.
For this, compounds of interest were tested in a series of two-fold dilutions, and the half maximum effective concentrations (EC50) which conferred 50% survival of the worms was determined.
Indeed, the half maximum effective concentrations (EC50) in all the three cell lines were four- to fivefold lower when calculated from the data of clonogenic assay than of MTS.
In our study, only bioassays containing both assay information of half-maximum inhibitory concentration (IC50), half-maximum effective concentration (EC50) or Ki values, and the explicit target sequence (GI) were systematically extracted from PubChem Bioassay database.
When several hormone concentrations were used, the concentration-response curves were analyzed for half-maximum effective concentration.
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