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This powerful approach can be applied by formulation scientists as an early and convenient tool in designing ASD formulations for maximum drug load and physical stability.
The total pore volume and the pore diameter of MSNs were the two main factors limiting the maximum drug load capacity.
The maximum drug load of JNJ-26483327 was 300 mg per capsule, resulting in a substantial capsule intake at the higher dose levels.
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When the PAC concentration was more than 300 mg/ml, csMSN had the maximum drug loading (45.7 ± 1.31%).
The process and formulation variables were optimized to achieve maximum drug loading content and entrapment efficiency by the desirability function.
The drug loading experiment of Zn-HAp nanoparticles was then confirmed with 1 mol% Zn-HAp (which had the maximum drug loading efficiency with pH responsive drug interaction).
With a view to obtain maximum drug loading three variables, concentration of drug solution, stirring rate, and drug carrier ratio were optimized using a full 33 factorial design.
Depending upon the co-polysaccharide:drug weight ratio (1 1, 1 2 and 1 3), a maximum drug loading (>95%) was noted at the lowest level.
Nevertheless, at maximum drug loading both systems remained stable for a long time.
Films formulated with gels combining CAR CMCMC : GLY (1 : 2 : 3) showed the maximum drug loading of 40% (of total dry weight) for paracetamol whilst those comprising SA : CMC : GLY (5 : 3 : 6) yielded films with a maximum amoxicillin loading of 26.3%.
Thus far, ASDs of model poorly water-soluble drugs such as diclofenac sodium, naproxen, piroxicam and indomethacin have been successfully incorporated in PHEMA hydrogels with a maximum drug loading up to approximately 40 50% w/ w.
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