Sentence examples for maximum drug effect from inspiring English sources
Chronotherapeutic drug delivery systems has a specificity in delivering therapeutic amount of drug in a burst at circadian timings correlated with specific pathological need to achieve maximum drug effect.
Based on the PK PD model results, for cefprozil twice daily, 50% and 80% of maximum drug effect (Emax) was achieved at a %T > MIC of approximately 52%and75%5%, respectively.
The proof showed that R0 was equivalent to the maximum drug effect parameter in the earlier application when the maximum inhibitory or stimulation effect Emax = 1.
The posterior distributions of (the maximum drug effect) for PASI75 and PGA responses at week 12 are similar, but the posterior distribution of (the placebo response) suggests a higher overall placebo response rate for PGA (12%) compared with PASI75 (4%).
The final model was simplified to include a common drug potency parameter (the daily sunitinib AUC resulting in half of the maximum drug effect, IC50) for all the four biomarkers that were found to be highly correlated for VEGF, sVEGFR-2, and sVEGFR-3 (75 92%).
This 2-h interval was chosen because maximal synergism of NGR hTNF with cytotoxic agents was observed with a 2-h delay between NGR hTNF and chemotherapy administration (Sacchi et al, 2006), thus suggesting a maximum drug effect on the vasculature at that time point.
Established analyzing procedures for ex-vivo chemosensitivity assays assume that the minimum and the maximum drug-effects are defined.
The delay to effect can arise because the site of action is not readily accessible to a drug, which may result in maximum effects occurring later than maximum drug concentrations.
The advantage of this transformation is that it allows Q to have a value from zero to infinity for D2RO from 0 to 100% and the drug effect to reach its maximum effect (Emax) for D2RO approaching 100% (Eq. 4).
In order to maximize the bactericidal effects of amino-glycosides, clinicians must optimize the maximum drug concentration to minimum inhibitory concentration ratio.
maximum drug concentration time.
