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Finally, the pharmacodynamics of antibiotics employed should always be considered in order to achieve maximum dosing and the best possible outcome.
This apparent disparity highlights the currently restrictive nature of a 20 mg maximum dosing, and that TDM may be clinically useful.
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If you took a couple acetaminophen for a headache until you got to the maximum dose, and then maybe later you take Tylenol PM and some Nyquil for a cold.
There is a large variation in the dose, maximum dose and re-dosing of gentamicin across ICUs.
Nonetheless, the performance of the various studied parameters (mean dose, maximum dose and cumulative dose) has been found to be systematically better when they are weight-based [26].
Likewise, weight-based maximum dose and weight-based cumulative dose were also similar to those observed for the entire group (respectively, 3.30 ± 2.49 and 353.30 ± 4458.19).
Norepinephrine is the recommended first-choice vasopressor with no recommendation for maximum dose and with early administration being associated with improved survival [8 11].
Homogeneity index, hot spot areas, the maximum dose, and the lung constraints were significantly reduced in the prone position (p < 0.05).
At first, by using the periodic table, we are requested to input the atomic number of the implanted ion species and the target structure, the number of layers, and the maximum dose and the dose step.
The maximum dose and duration of indomethacin in our patients were: 150 mg tid for 6 weeks (case 1), 150 mg tid for 2 weeks (case 2), and 100 mg tid for 6 weeks (case 3).
There was no difference between the initial and maximum doses and infusion length.
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